Tobradex steroid

Corticosteroids have been used as drug treatment for some time. Lewis Sarett of Merck & Co. was the first to synthesize cortisone, using a complicated 36-step process that started with deoxycholic acid, which was extracted from ox bile . [43] The low efficiency of converting deoxycholic acid into cortisone led to a cost of US $200 per gram. Russell Marker , at Syntex , discovered a much cheaper and more convenient starting material, diosgenin from wild Mexican yams . His conversion of diosgenin into progesterone by a four-step process now known as Marker degradation was an important step in mass production of all steroidal hormones, including cortisone and chemicals used in hormonal contraception . [44] In 1952, . Peterson and . Murray of Upjohn developed a process that used Rhizopus mold to oxidize progesterone into a compound that was readily converted to cortisone. [45] The ability to cheaply synthesize large quantities of cortisone from the diosgenin in yams resulted in a rapid drop in price to US $6 per gram, falling to $ per gram by 1980. Percy Julian's research also aided progress in the field. [46] The exact nature of cortisone's anti-inflammatory action remained a mystery for years after, however, until the leukocyte adhesion cascade and the role of phospholipase A2 in the production of prostaglandins and leukotrienes was fully understood in the early 1980s.

UNIT OF USE

NDC 0065-0647-25

Alcon ®

TobraDex ®
(tobramycin and dexamethasone ophthalmic suspension)

Sterile mL

Rx Only

EACH ML CONTAINS:
Actives: tobramycin % (3 mg) and dexamethasone % (1 mg).
Preservative: benzalkonium chloride %.
Inactives: tyloxapol, edetate disodium, sodium chloride, hydroxyethyl cellulose, sodium sulfate, sulfuric acid and/or sodium hydroxide (to adjust pH), purified water.

PRECAUTION: Do not touch dropper tip to any surface, as this may contaminate the suspension. FOR TOPICAL OPHTHALMIC USE ONLY. Read enclosed insert.

STORAGE: Store upright at 8º-27ºC (46º-80ºF).

SHAKE WELL BEFORE USING.

ALCON LABORATORIES, INC.
Fort Worth,Texas 76134 USA
 
Printed in USA
© 2000, 2010 Alcon, Inc.

LOT:

EXP.:

H13354-0214

UNIT OF USE

NDC 0065-0647-25

Alcon ®

TobraDex ®
(tobramycin and dexamethasone ophthalmic suspension)

Sterile mL

Rx Only

EACH ML CONTAINS:
Actives: tobramycin % (3 mg) and dexamethasone % (1 mg).
Preservative: benzalkonium chloride %.
Inactives: tyloxapol, edetate disodium, sodium chloride, hydroxyethyl cellulose, sodium sulfate, sulfuric acid and/or sodium hydroxide (to adjust pH), purified water.

PRECAUTION: Do not touch dropper tip to any surface, as this may contaminate the suspension. FOR TOPICAL OPHTHALMIC USE ONLY. Read enclosed insert.

STORAGE: Store upright at 8º-25ºC (46º-77ºF).

SHAKE WELL BEFORE USING.

ALCON LABORATORIES, INC.
Fort Worth,Texas 76134 USA
 
Printed in USA

© 2000, 2015 Novartis

LOT:

EXP.:

H14081-1015

Tobradex steroid

tobradex steroid

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