Q. What is Liver Cirrhosis? I read that alcohol can lead to liver cirrhosis. What does cirrhosis mean? A. The word "cirrhosis" is a neologism that derives from Greek kirrhos, meaning "orange-yellow". In this condition, the liver appears yellow in pathology from all the tissue changes and damage caused to it. Cirrhosis has many possible causes. Sometimes more than one cause is present in the same patient. In the Western World, chronic alcoholism and hepatitis C are the most common causes. The sick liver gradually loses its function, therefore leading to end stage liver disease that ultimately requires liver transplant.