Indole alkaloids comprise serotonin chemically know as 5-hydroxyltryptamine or 5-HT and others of their kind. These comprise the anesthetizing alkaloids of the passion flower , ophthalmic alkaloids associated with the physostigmine derived from the calabar bean as well as the uterine tonics such as ergotamine. This variety of alkaloids also comprises the Indian snakeroot or the Rauwolfia serpentaria that consist of reserpine. It may be mentioned here that reserpine contains potent hypotensive and when isolated from the entire plant possess depressive consequences. Among the numerous central nervous stimulants such as strychnine, psilocybin and johimbine, indole alkaloids comprise indole carbon-nitrogen loop. Indole carbon-nitrogen ring is also present in the fungal alkaloids ergine and psilocybin, the neurotransmitter serotonin as well as the mind jerking medication LSD. Researches have shown that these alkaloids may often impede, obstruct or even contend with the action of serotonin in the brain.
Is a condition where the mare’s behaviour is due to hormone disruption. Sometimes Ovaries are blamed for a range of problems, including lameness and training issues, so first rule out other causes. If she’s harder to ride or doesn’t perform well during oestrus, you may decide to just take it easy or give her time off on those days. But if you need to stick to a competition or training schedule, you may decide to control the timing of her heat cycle with hormone therapy. Some mares are reactive, hard to handle or unfocused in their work while in heat. Oestrogen brings the mare into heat and prepares her reproductive tract for breeding, while progesterone keeps her out of heat. In the non-pregnant mare, interaction of oestrogen and progesterone are the main factors that determine her behaviour, personality, and pain threshold. Again there are drugs and herbs that can influence the balance between oestrogen and progesterone as well as addressing the pain threshold by increasing serotonin levels.
Man has a long history with ergot – a fungus which infects rye (which is then transferred to humans who eat the grain). Ergotism causes hallucinations and attendant irrational behavior, convulsions, and even death. Other symptoms include strong uterine contractions, nausea, seizures, and unconsciousness. Consumption can lead to amputation of limbs which are damaged by the fungus. Since the middle ages, controlled doses of ergot were used to induce abortions and to stop maternal bleeding after childbirth. Ergot alkaloids are used in products such as Cafergot (containing caffeine and ergotamine or ergoline) to treat migraine headaches. It is also used in a variety of treatments for Parkinson’s disease. Ergotism has even been blamed (though it is not likely the true cause) for the extremely bizarre dancing plague which struck Europe in the 1500s .