The Union Association survived for only one season (1884), as did the Players' League (1890), an attempt to return to the National Association structure of a league controlled by the players themselves. Both leagues are considered major leagues by many baseball researchers because of the perceived high caliber of play and the number of star players featured. However, some researchers have disputed the major league status of the Union Association, pointing out that franchises came and went and contending that the St. Louis club, which was deliberately "stacked" by the league's president (who owned that club), was the only club that was anywhere close to major league caliber.
Corticosteroids are generally teratogenic in laboratory animals when administered systemically at relatively low dosage levels. The more potent corticosteroids have been shown to be teratogenic after dermal application in laboratory animals. There are no adequate and well controlled studies in pregnant women on teratogenic effects from topically applied corticosteroids. Therefore, topical corticosteroids should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Drugs of this class should not be used extensively on pregnant patients, in large amounts, or for prolonged periods of time.