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Vasopressin hormones are a family of peptides released from the hypothalamus derived from a common pre pro form. We aim to identify longitudinal reference levels in a large cohort of CKD patients to correlate with disease stage. Also, such data from heart failure patients will be assessed. We plan to evaluate e. g. effects of circadian rhythm, comorbidities and respective treatments, demographics and life style on hormone levels. A definition of cut-off levels could help to identify patients at risk for worsening conditions (such as loss of kidney function in CKD) or to predict progression or outcome of treatment.