Adrenal steroidogenesis pathway

The human adrenal gland is composed of the cortex and the medulla. The medulla produces bioamines, and the adrenal cortex secretes several classes of steroids (corticosteroids). The adrenal cortex can be considered to be made up of three distinct subunits, each having a characteristic steroid profile. The outermost unit, the zona glomerulosa, produces mineralocorticoids, principally aldosterone (a salt-retaining hormone), which serve to maintain sodium and fluid balance. Glucocorticoids, primarily cortisol, arise from the central zona fasciculata and maintain glucose homeostasis and vascular integrity. The innermost subunit, the zona reticularis, secretes sex steroids (androgens). Disorders of adrenal steroidogenesis may involve overproduction, underproduction, or both the simultaneous overproduction and underproduction of corticosteroids ( Fig. 8-1 ). In this chapter, the following conditions are discussed:

Adrenal steroidogenesis pathway

adrenal steroidogenesis pathway

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